发明名称 |
METABOLICALLY OPTIMIZED CELL CULTURE |
摘要 |
An improved method for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method provides for culturing cells that have metabolically shifted. The use of such a method or system allows high levels of protein or polypeptide production and reduces accumulation of unwanted metabolic waste such as lactate. Proteins and polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, immunogenic, or other commercial biologic compositions, such as antibodies. |
申请公布号 |
EP3055409(A4) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20140851841 |
申请日期 |
2014.10.10 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
LAWRENCE, SHAWN;KIM, ANN;JOHNSON, AMY |
分类号 |
C12N5/02;C12N5/16 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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