发明名称 |
IMPROVED DELIVERY OF POORLY WATER SOLUBLE DRUGS WITH ALPHAFETOPROTEIN STABILIZED WITH METAL IONS |
摘要 |
The invention discloses a novel significantly improved carrier protein for pharmaceutical applications: metal ion-stabilized alfa-fetoprotein, AFP. The stabilized AFP serves as a novel universal drug delivery vehicle in formulating drugs to be targeted to cancer cells. Various transition metal ions form non-covalent adducts with AFP and stabilize it against physical and chemical factors in physiological fluids while not affecting its ability to target to AFP receptor-expressing cells. |
申请公布号 |
EP3071239(A1) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20140864437 |
申请日期 |
2014.11.18 |
申请人 |
OY SAFEMED LTD |
发明人 |
DUDICH, IGOR VYACHESLAVOVITCH;SEMENKOVA, LIDIA NIKOLAEVNA;TATULOV, EDUARD;KORPELA, TIMO |
分类号 |
A61K47/48;A61K33/30;A61K38/17;C07K14/47 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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