发明名称 |
REPERFUSION WITH OMEGA-3 GLYCERIDES PROMOTES DONOR ORGAN PROTECTION FOR TRANSPLANTATION |
摘要 |
It has been discovered that isolated organs and tissues perfused/reperfused in perfusion buffer to which omega-3 glyceride oil had been added retain higher levels of function than if perfused/reperfused without the omega-3 glycerides. Isolated hearts reperfused ex vivo after induced ischemia in n-3 triglyceride perfusion emulsion maintained a normal heart rate and normal LVDP and showed a dramatically reduced frequency of arrhythmias compared to control hearts. Further, test hearts reperfused with n-3 oil triglyceride emulsion showed a decrease in creatine kinase and upregulation of certain beneficial proteins including the anti-apoptotic gene marker Bcl-2. |
申请公布号 |
EP2978307(A4) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20140775254 |
申请日期 |
2014.03.28 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
DECKELBAUM, RICHARD J.;RAMASAMY, RAVICHANDRAN |
分类号 |
A01N1/02;A61K31/202 |
主分类号 |
A01N1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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