SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS
摘要
Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
申请公布号
EP3071553(A1)
申请公布日期
2016.09.28
申请号
EP20130897883
申请日期
2013.11.21
申请人
PTC THERAPEUTICS, INC.
发明人
BAIAZITOV, RAMIL;CHOI, SOONGYU;DU, WU;HWANG, SEONGWOO;LEE, CHANG-SUN;LIU, RONGGANG;MOON, YOUNG-CHOON;PAGET, STEVEN D.;REN, HONGYU;SYDORENKO, NADIYA;WILDE, RICHARD GERALD
