摘要 |
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
PASTERNAK, ALEXANDER;DE JESUS, REYNALDA KEH;DING, FA-XIANG;DONG, SHUZHI;FRIE, JESSICA;GU, XIN;JIANG, JINLONG;SHAHRIPOUR, AURASH;PIO, BARBARA;TANG, HAIFENG;WALSH, SHAWN |