发明名称 |
COMPOSITIONS AND METHODS OF USING TRANSPOSONS |
摘要 |
The present invention provides compositions and methods of using transposons. In one aspect, methods are disclosed that are useful for identifying negatively selected genes in an insertional mutagenesis screen. In another aspect, compositions for reducing proliferation of a tumor cell expressing an oncogenic RAS include an activator of a WNT pathway. Pharmaceutical compositions for reducing proliferation of tumor cells in a subject in need thereof by administering an effective amount of an activator of a WNT pathway to the tumor cells of the subject are also disclosed. |
申请公布号 |
EP3071689(A1) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20140861901 |
申请日期 |
2014.11.17 |
申请人 |
YALE UNIVERSITY |
发明人 |
XU, TIAN;QIAN, FENG;LANDRETTE, SEAN |
分类号 |
C12N5/10 |
主分类号 |
C12N5/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|