发明名称 |
THROMBORESISTANT/BACTERICIDAL S-NITROSO-N-ACETYLPENICILLAMINE (SNAP)-DOPED NITRIC OXIDE RELEASE POLYMERS WITH ENHANCED STABILITY |
摘要 |
A polymeric film includes a polymer matrix having at least one of a discrete RSNO adduct or a polymeric RSNO adduct associated therewith, by: covalent attachment to the polymer matrix; dispersion within the polymer matrix; or both, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, or a copolymer matrix of polyurethane and silicone rubber. The polymeric film is to exhibit stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to moisture or light capable of photolyzing an RSNO bond, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct. |
申请公布号 |
EP2953660(A4) |
申请公布日期 |
2016.09.21 |
申请号 |
EP20140748530 |
申请日期 |
2014.02.06 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
BRISBOIS, ELIZABETH, J.;HANDA, HITESH;MEYERHOFF, MARK, E. |
分类号 |
A61L33/06;A61L27/14;A61L29/12;A61L29/16;A61L33/02 |
主分类号 |
A61L33/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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