| 摘要 |
The present invention relates to new substituted pyrazolo [3,4- d ]pyrimidine compounds of general formula (I), having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of i.a. pain.
n is selected from 1, 2, 3 or 4; R 1 represents a carbon-linked optionally substituted aryl or heteroaryl radical; R 2 and R 3 independently represent a hydrogen atom, an optionally substituted aliphatic, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl radical, or R 2 and R 3 together with the bridging nitrogen form an optionally substituted heterocyclyl or heteroaryl radical. |
