| 摘要 |
The present invention provides for novel glycoproteins comprising therapeutically useful polypeptides, or fragments or variants thereof, conjugated to glycosylated amino acid block copolymer polypeptides. These novel glycoproteins possess improved half-life properties as compared to the unmodified therapeutically useful polypeptide. Furthermore, the invention encompasses methods for designing and synthesizing nucleic acid molecules encoding these novel glycoproteins, cloning recombinant expression vectors containing these nucleic acid molecules, making host cells transformed with these nucleic acid expression vectors, and recombinantly expressing, purifying and characterizing the novel glycoproteins of the invention. Additionally the present invention encompasses pharmaceutical compositions comprising these novel glycoproteins, as well as methods of treating, preventing or ameliorating disease, disorders or conditions using novel glycoproteins of the invention. |
