TETRACYCLIC AUTOTAXIN INHIBITORS

摘要

Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

主权项

1. A compound having the structure of Formula (VI), or a pharmaceutically acceptable salt or solvate thereof: wherein, R1 is H, halogen, —CN, —OH, C1-C4alkyl, C1-C4fluoroalkyl, or C1-C4deuteroalkyl; R3 is H, F, C1-C4alkyl, or C1-C4fluoroalkyl; R4 is H, F, C1-C4alkyl, or C1-C4fluoroalkyl; R7 is H, or F; each RA substituent is independently H, halogen, OH, —O—C1-C4alkyl, —CN, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
n is 0, or 1; X is —CH═, —N═, or —CF═; and W is —C(═O)—, —C(═S)—, or —CH2—.