Dithiol Compounds, Derivatives, and Uses Therefor

摘要

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

主权项

1. A a compound having the structure of Formula I or I-NC, or a pharmaceutically acceptable salt thereof: wherein at least one of X and Y is sulfur, and the other is sulfur, selenium, or a sulfonic group; R19 is substituted or unsubstituted alkylene; R20, R21, R30, and R31 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; wherein R30 and R31 may optionally be joined together or together form a single bond; Z is N and m is 1.