COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASES USING FOXP3

摘要

The methods and systems of the present invention provide for an expression vector containing a disease-specific promoter or a constitutive promoter linked to a gene encoding a therapeutic agent, such as a protein, microRNA, siRNA or other therapeutical molecule, e.g., other oligonucletide. The therapeutic agent may be, for example, Interleukin 10 (IL10), Forkhead box P3 (FOXP3), or a member of a transforming growth factor beta 1 (TGFβ1) signaling pathway, such as SMAD3.

主权项

1. A method of treating a cardiovascular disease in a subject, comprising the step of administering to the subject a vector comprising a cDNA encoding a FOX (Forkhead box) protein, wherein the cDNA is under control of a disease-specific or constitutive promoter.