发明名称 METHOD FOR SYNTHESISING PHARMACEUTICAL INTERMEDIATE PHENANTHRENE COMPOUND IN POTASSIUM TERT-BUTOXIDE ENVIRONMENT
摘要 The present invention relates to a method for synthesising a phenanthrene compound as shown in formula (I) in a potassium tert-butoxide environment, the method comprising: reacting the compound of formula (II) with the compound of formula (III) in an inert atmosphere, in the presence of a catalyst, organic ligands and potassium tert-butoxide, and in a solvent, thereby obtaining the compound of formula (I), wherein R1 and R2 are each independently H, a C1-C6 alkyl group, a C1-C6 alkoxy group or a halogen, R3 is a C6-C10 aryl group or a C5-C8 heteroaryl group, the C6-C10 aryl group or the C5-C8 heteroaryl group being optionally substituted by 1-3 substituents, the substituents being C1-C6 alkyl groups or halogens. The method obtains a good effect via the selection of an appropriate catalyst, organic ligands, base and solvent, and has wide prospects for industrial application.
申请公布号 WO2016141826(A1) 申请公布日期 2016.09.15
申请号 WO2016CN75403 申请日期 2016.03.03
申请人 JIN, Yinghua 发明人 ZHAI, Xueyan
分类号 C07B37/10;C07C2/42;C07C15/30;C07C17/275;C07C25/22;C07D213/127;C07D213/16 主分类号 C07B37/10
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