发明名称 |
Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells |
摘要 |
The present invention provides for nucleic acids improved for the expression of interleukin- 15 (IL- 15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-15 sequence. The present invention further provides expression vectors, and IL- 15 and IL- 15 receptor alpha combinations (nucleic acid and protein) that increase IL- 15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human). |
申请公布号 |
AU2016216577(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
AU20160216577 |
申请日期 |
2016.08.16 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY |
发明人 |
FELBER, BARBARA K.;PAVLAKIS, GEORGE N. |
分类号 |
C12N15/67;A61K38/17;A61K38/20;C07K14/54;C07K14/715 |
主分类号 |
C12N15/67 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|