发明名称 |
PHOSPHODIESTERASE 5A INHIBITORS FOR THE TREATMENT OF MUSCULAR DYSTROPHY |
摘要 |
Described herein are methods of treating muscular dystrophy, including Becker's muscular dystrophy and Duchenne muscular dystrophy. The methods comprise administering a phosodiesterase 5A (PDE5A) inhibitor, such as tadalafil, to a subject in need thereof. Administering the PDE5A inhibitor has beneficial effects such as restoring functional sympatholysis, alleviating ischemic insult to dystrophin-deficient muscle membranes, reducing use-dependent muscle injury, and thus can slow muscular dystrophy disease progression. |
申请公布号 |
EP2986301(A4) |
申请公布日期 |
2016.09.14 |
申请号 |
EP20140850303 |
申请日期 |
2014.04.21 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
VICTOR, RONALD G.;THOMAS, GAIL D. |
分类号 |
A61K31/4985;A61K31/519;A61K31/53;A61P21/00 |
主分类号 |
A61K31/4985 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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