Stabilized alpha-galactosidase and uses thereof

摘要

Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well as a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed mulitmeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.