发明名称 |
QUINOLINE AND CINNOLINE DERIVATIVES AND USE THEREOF |
摘要 |
The present invention relates to a series of quinoline and cinnoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and/or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and/or prevention of cancer. |
申请公布号 |
EP2799437(B1) |
申请公布日期 |
2016.09.14 |
申请号 |
EP20120862344 |
申请日期 |
2012.12.07 |
申请人 |
SHENYANG PHARMACEUTICAL UNIVERSITY;SHENYANG PHARMACEUTICAL UNIVERSITY (BENXI) PHARMACEUTICAL SCIENCE AND TECHNOLOGY CO., LTD |
发明人 |
GONG, PING;ZHAO, YANFANG;LIU, YAJING;ZHAI, XIN;LI, SAI;ZHU, WUFU;QIN, MINGZE |
分类号 |
C07D401/12;A61K31/496;A61K31/502;A61K31/506;A61K31/5377;A61P35/00;C07D401/14;C07D403/12 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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