| 摘要 |
The present invention provides chromatographic means for separating from a starting lipid mixture a mixture that is enriched in docosapentaenoic acid relative to the starting lipid mixture. The invention also provides pharmaceutical formulations and dietary supplements including this enriched lipid formulation, and methods of supplementing docosapentaenoic acid in a subject by administering to the subject the pharmaceutical formulation or the dietary supplement. The invention also provides a method of resolving from the starting lipid mixture a mixture enriched in docosahexaenoic acid and eicosapentaenoic acid and depleted in docosapentaenoic acid, and formulations including this mixture (e.g., pharmaceutical formulations and dietary supplements). Also provided are methods of supplementing docosapentaenoic acid and eicosapentaenoic acid levels in a subject by administering a formulation of the invention to the subject. In various embodiments, the formulations of the invention are of use to lower cholesterol, triglyceride, glucose levels, and inflammation in the subject to whom the formulation is administered. |
