METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END

摘要

A method simply produces a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end without using a heavy metal catalyst. A method for producing a polyalkylene glycol derivative having an amino group at the end by reacting a compound represented by the general formula (V) with an alkylene oxide, then reacting a reaction product with an electrophile represented by the general formula (I), and deprotecting the obtained product without using a heavy metal:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR A 3 o(R A 4 O) k-1 R A 4 O - M + €ƒ€ƒ€ƒ€ƒ€ƒ(V)
wherein R A 3 represents a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms; R A 4 represents an alkylene group having 2 to 8 carbon atoms; k represents an integer of 2 to 5; and M represents an alkali metal;
wherein R A 1a and R A 1b each independently represent a protective group of the amino group, or one of R A 1a and R A 1b represents H and the other represents a protective group of the amino group, or R A 1a and R A 1b bind to each other to form a cyclic protective group, and the protective group is deprotectable without using a heavy metal; R A 2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; and X represents a leaving group.