TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE MANUFACTURED BY CO-EXTRUSION.

摘要

11GRA3639-WO/JBdk Summary: The invention relates toa monolithic pharmaceutical dosage form comprising a hot melt-extruded first segment (S ) and a second segment (S 2 ); whereinthe first segment (S ) contains at least a first pharmacologically active ingredient (A ) and/or the second segment (S 2 )contains at least a second pharmacologically active ingredient (A 2 ); andthe segment (S ) and/or the segment (S 2 ) is tamper-resistantand/orexhibits a breaking strength of at least 300N.