发明名称 |
Compositions and methods for treating hepatitis C virus |
摘要 |
The invention relates to medicine, in particular to pharmacology and infectious diseases, namely to compositions and unit dosage forms for the treatment of hepatitis C virus infection.The pharmaceutical composition comprises:a) about 25% to about 35% w/w of crystalline form having the structure:(GS-7977); andb) at least one pharmaceutically acceptable excipient,wherein the crystalline GS-7977 has HRPD 2θ-reflections (°) at about: 6.1 and 12.7.According to the invention, also disclosed are methods of treating subjects infected with hepatitis C virus comprising administering to the subjects for a time period effective amounts of GS-7977 and of interferon-free ribavirin. |
申请公布号 |
MD4430(B1) |
申请公布日期 |
2016.08.31 |
申请号 |
MD20140000058 |
申请日期 |
2012.11.27 |
申请人 |
GILEAD PHARMASSET LLC |
发明人 |
CLEARY Darryl G.;REYNOLDS Charles J.;BERREY Miriam Michelle;HINDES Robert G.;SYMONDS William T.;RAY Adrian S.;MO Hongmei;HEBNER Christy M.;OLIYAI Reza;ZIA Vahid;STEFANIDIS Dimitrios;PAKDAMAN Rowchanak;CASTEEL Melissa Jean |
分类号 |
A61K31/4196;A61K9/20;A61K31/513;A61P31/14 |
主分类号 |
A61K31/4196 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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