| 摘要 |
The present invention relates to a process for the preparation of a compound of formula (I), hydrates or solvates thereof:said process comprising the steps of: a) reacting a compound of formula (II) with an acylating or a silylating agent to produce a compound of formula (III)wherein Pis a protecting group selected from RCO- or RSi(R)(R)-, Pis a protecting group selected from (RRR)C-CO- or (R)Si(R)(R)-, wherein Ris a group selected from Calkyl or Ccycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; R, Rand Rare each independently a group selected from Calkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; Ris a group selected from Calkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; Rand Rare each independently hydrogen or a group selected from Calkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; b) reacting the compound of formula (III) in the presence of at least one oxidizing agent selected from permanganate salt, osmium oxide, hydrogen peroxide or iodine and silver acetate to produce a compound of formula (IV)and c) deprotecting the compound of formula (IV) to produce the compound of formula (I). |
