| 摘要 |
Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n; R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2); n : 1-3; R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3; R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6; R, R4 : H, 1-12C alkyl or optionally substituted aryl; R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR); R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR); B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR); R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8; and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I); and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given. |
