发明名称 |
METHOD FOR PRODUCING HEMATOPOIETIC STEM CELLS USING PYRAZOLE COMPOUND |
摘要 |
An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R 1 to R 8 are as defined in the description). |
申请公布号 |
EP2647697(B1) |
申请公布日期 |
2016.08.24 |
申请号 |
EP20110845184 |
申请日期 |
2011.12.01 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD.;REPROCELL INCORPORATED |
发明人 |
NISHINO, TAITO;YUI, MAKIKO;ASAI, YASUYUKI |
分类号 |
C12N5/00;A61K35/12;A61K35/14;A61K35/28;A61K35/37;A61K35/407;A61K35/44;A61P1/16;A61P3/10;A61P5/14;A61P7/00;A61P7/04;A61P7/06;A61P9/10;A61P13/12;A61P17/02;A61P19/02;A61P21/00;A61P21/04;C12N5/0789 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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