发明名称 |
MEROPENEM DERIVATIVES AND USES THEREOF |
摘要 |
The present invention provides novel derivative of &bgr;-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection). |
申请公布号 |
EP2968274(A4) |
申请公布日期 |
2016.08.24 |
申请号 |
EP20140762750 |
申请日期 |
2014.03.14 |
申请人 |
KALA PHARMACEUTICALS, INC. |
发明人 |
ONG, WINSTON ZAPANTA;NOWAK, PAWEL WOJCIECH;KIM, JINSOO;ENLOW, ELIZABETH M.;BOURASSA, JAMES;CU, YEN;POPOV, ALEXEY;CHEN, HONGMING |
分类号 |
A61K31/407;C07D477/20;C07D487/04 |
主分类号 |
A61K31/407 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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