| 主权项 |
1. A compound of the formula in which R1 represents a group of the formula where # is the point of attachment to the nitrogen atom,R5 represents 5-membered heteroaryl,
where heteroaryl may be substituted by a substituent selected from the group consisting of oxo, chlorine, cyano, hydroxyl and C1-C3-alkyl,
in which alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting ofhydroxy, amino, hydroxycarbonyl and methoxy, orin which alkyl may be substituted by 1 to 7 fluorine substituents, orin which alkyl is substituted by a substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, and in which alkyl is additionally substituted by 1 to 6 fluorine substituents,R6 represents hydrogen, fluorine or chlorine,R7 and R8 together with the carbon atoms to which they are attached form a 5-membered heterocycle,
where the heterocycle may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, chlorine, cyano, hydroxyl, C1-C3-alkyl, pyrazolyl and pyridyl,
in which alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, orin which alkyl may be substituted by 1 to 7 fluorine substituents, orin which alkyl is substituted by a substituent selected from the group consisting of hydroxy, amino, hydroxycarbonyl and methoxy, and in which alkyl is additionally substituted by 1 to 6 fluorine substituents,R9 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, fluorine, chlorine, methyl or methoxy, R3a represents hydrogen, fluorine, chlorine, C1-C4-alkyl, methoxy or trifluoromethyl, R3b represents hydrogen or fluorine, R4 represents amino, cyano, hydroxymethyl, methyl, C1-C3-alkoxy, C1-C3-alkylamino, C1-C3-alkoxycarbonyl, —S(O)2NR10R11, —C(O)NR12R13 or —NR14(CO)R15,
where alkoxy is substituted by 1 to 2 substituents independently of one another selected from the group consisting of fluorine, hydroxy, amino, hydroxycarbonyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, —(OCH2CH2)n—OCH3, —(OCH2CH2)m—OH, morpholinyl, piperidinyl and pyrrolidinyl,
in which n is a number from 1 to 6,in which m is a number from 1 to 6, andwhere methyl is substituted by 5- or 6-membered heterocyclyl which is attached via a nitrogen atom, andwhere
R10 represents hydrogen, C1-C3-alkyl, C3-C6-cycloalkyl, benzyl or 4- to 8-membered heterocyclyl which is attached via a carbon atom,R11 represents hydrogen or C1-C3-alkyl, orR10 and R11 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle,in which the heterocycle may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, fluorine, hydroxyl, amino, hydroxycarbonyl, C1-C4-alkyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroeth-1-yl, C1-C4-alkoxycarbonyl, aminocarbonyl and C1-C3-alkylaminocarbonyl,R12 represents hydrogen, C1-C3-alkyl, C1-C3-alkoxy, C3-C6-cycloalkyl, benzyl or 4- to 8-membered heterocyclyl which is attached via a carbon atom,
in which alkyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of fluorine, hydroxy, amino, hydroxycarbonyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, —(OCH2CH2)n—OCH3, —(OCH2CH2)m—OH, morpholinyl, piperidinyl and pyrrolidinyl, in which n is a number from 1 to 6, in which m is a number from 1 to 6, andin which cycloalkyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, fluorine, hydroxy, amino, C1-C4-alkyl and C1-C3-alkylamino,
in which alkyl and alkylamino for their part may be substituted by 1 to 5 fluorine substituents, andin which heterocyclyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, fluorine, hydroxy, amino, hydroxycarbonyl, C1-C4-alkyl, C1-C3-alkylamino, C1-C4-alkoxycarbonyl, aminocarbonyl and C1-C3-alkylaminocarbonyl,
in which alkyl and alkylamino for their part may be substituted by 1 to 5 fluorine substituents, andin which heterocyclyl may additionally be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine and methyl,R13 represents hydrogen or C1-C3-alkyl, orR12 and R13 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle,
in which the heterocycle may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, fluorine, hydroxyl, amino, hydroxycarbonyl, C1-C4-alkyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroeth-1-yl, C1-C4-alkoxycarbonyl, aminocarbonyl and C1-C3-alkylaminocarbonyl,
in which alkyl for its part may be substituted by a hydroxy substituent,R14 represents hydrogen or C1-C3-alkyl,R15 represents C1-C4-alkyl, C3-C6-cycloalkyl, phenyl or 5- to 7-membered heterocyclyl,
in which alkyl may be substituted by a substituent selected from the group consisting of C1-C3-alkylamino and —NH(CO)CH2NH(CO)CH2NH2, or one of the salts thereof, solvates thereof or solvates of the salts thereof. |
