发明名称 |
HMG−CoA還元酵素阻害剤及びイルベサルタンを含む二層錠の薬学的剤型 |
摘要 |
Provided is a pharmaceutical formulation in the form of a bilayered tablet consisting of a first layer containing irbesartan or a pharmaceutically acceptable salt thereof and a second layer containing an HMG-CoA reductase inhibitor and a basic additive, which can improve the dissolution rate and stability of irbesartan and an HMG-CoA reductase inhibitor to enhance the bioavailability of the drug compared to conventional complex formulations and to minimize the generation of the related compounds, thereby being effectively used as a stable and superior therapeutic agent for hypertension and hypercholesterolemia. |
申请公布号 |
JP5969466(B2) |
申请公布日期 |
2016.08.17 |
申请号 |
JP20130510029 |
申请日期 |
2011.05.13 |
申请人 |
ハンミ・サイエンス・カンパニー・リミテッド |
发明人 |
キム ヨンイル;ナ ヨンジュン;キム ミンジョン;キム ヨンフン;パク ジェヒョン;ウ ジョンス |
分类号 |
A61K31/40;A61K9/20;A61K31/4184;A61K47/02;A61K47/10;A61K47/12;A61K47/26;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61P3/06;A61P9/12;A61P43/00 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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