发明名称 |
ANTIDIABETIC TRICYCLIC COMPOUNDS |
摘要 |
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslip idemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. |
申请公布号 |
EP3055288(A1) |
申请公布日期 |
2016.08.17 |
申请号 |
EP20140852689 |
申请日期 |
2014.09.30 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BIFTU, TESFAYE;BIJU, PURAKKATLE;COLLETTI, STEVEN L.;CUI, MINGXIANG;HAGMANN, WILLIAM K.;HU, BIN;JOSIEN, HUBERT;KAR, NAM FUNG;NAIR, ANILKUMAR;NARGUND, RAVI;SPERBECK, DONALD M.;ZHU, CHEN |
分类号 |
C07D221/16;A61K31/435;A61K31/444;A61P3/10;C07D401/12;C07D405/12 |
主分类号 |
C07D221/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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