发明名称 |
MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES |
摘要 |
Disclosed are methods for treating an individual infected with a retrovirus that comprise administering to the individual effective amounts of a mixed lineage kinase inhibitor and antiretroviral drug. In further aspects, disclosed are methods for treating an individual infected with a retrovirus that comprises administering an antiretroviral drug formulated into a crystalline nanoparticle comprising a surfactant, and a MLK inhibitor. Still further disclosed are methods for treating an individual infected with a retrovirus that comprises administering a composition comprising both an antiretroviral and MLK inhibitor formulated into a crystalline nanoparticle, which comprises a surfactant. Still further disclosed are compositions that comprise an antiretroviral drug, a MLK inhibitor, and a surfactant, wherein the composition is a crystalline nanoparticle. Compostions comprising MLK inhibitors with other drugs in nanoparticulate form, and methods of there use, are also disclosed. |
申请公布号 |
EP2925319(A4) |
申请公布日期 |
2016.08.17 |
申请号 |
EP20130857739 |
申请日期 |
2013.11.30 |
申请人 |
UNIVERSITY OF ROCHESTER;BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA |
发明人 |
GELBARD, HARRIS A.;DEWHURST, STEPHEN;GENDELMAN, HOWARD E. |
分类号 |
A61K31/427;A61K31/437;A61K31/4418;A61K31/444;A61K31/496;A61K31/506;A61K31/536;A61K31/553;A61K45/06;A61P31/18 |
主分类号 |
A61K31/427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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