发明名称 |
RETINOL-MODIFIED COLLAGEN, METHOD FOR PRODUCING SAME, AND EXTERNAL COMPOSITION FOR SKIN CONTAINING SAME |
摘要 |
Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. |
申请公布号 |
EP2583977(B1) |
申请公布日期 |
2016.08.17 |
申请号 |
EP20110795768 |
申请日期 |
2011.06.15 |
申请人 |
NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OFSCIENCE AND TECHNOLOGY;SUNSTAR INC. |
发明人 |
TANIHARA, MASAO;TAKAICHI, KANA;MAEDA, MARIKO;MITSUI, TSUKASA;YAMAMOTO, KAZUSHI;HIRANO, AKIKO |
分类号 |
C12N15/09;A61K8/65;A61K8/67;A61K31/07;A61K38/00;A61P17/00;A61Q19/00;C07K14/78 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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