| 发明名称 |
Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban |
| 摘要 |
Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified. |
| 申请公布号 |
EP3009435(B1) |
申请公布日期 |
2016.08.17 |
| 申请号 |
EP20140189007 |
申请日期 |
2014.10.15 |
| 申请人 |
F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A. |
发明人 |
BRASOLA, ELENA;TOMASI, FILIPPO |
| 分类号 |
C07D471/04 |
主分类号 |
C07D471/04 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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