PEPTIDIC ANTAGONIST OF THE BINDING BETWEEN CD47 AND A PROTEIN BELONGING TO THE FAMILY OF THROMBOSPONDIN
摘要
Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.
申请公布号
EP2729495(B1)
申请公布日期
2016.08.17
申请号
EP20120738574
申请日期
2012.07.06
申请人
UNIVERSITÉ DE REIMS CHAMPAGNE-ARDENNE
发明人
DEDIEU, STÉPHANE;FLOQUET, NICOLAS;MARTINY, LAURENT;SCHNEIDER, CHRISTOPHE;JEANNE, ALBIN;SICK, EMILIE;DAUCHEZ, MANUEL