微粉化オピオイド組成物、製剤および剤形、ならびにそれらの製造方法

摘要

Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a DV 90 particle size distribution of less and or equal to 10µ or less than or equal to 20µ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.