发明名称 |
SYNTHESIS OF 1-ALKYL-2-AMINO-IMIDAZOL-5-CARBOXYLIC ACID ESTER VIA CALPHA-SUBSTITUTED N-ALKYL-GLYCINE ESTER DERIVATIVES |
摘要 |
The invention provides an efficient and high yielding process for preparing TH-302, comprising at least one step wherein a dioxolane intermediate is generated in an aqueous layer, resulting in a synthesis that is amenable to scale up conditions. |
申请公布号 |
EP3055295(A1) |
申请公布日期 |
2016.08.17 |
申请号 |
EP20140789990 |
申请日期 |
2014.10.10 |
申请人 |
MERCK PATENT GMBH |
发明人 |
JASPER, CHRISTIAN;HAHN, HELMUT DIETER;BREUNING, MARCEL ANDRÉ;KRATTIGER, PHILIPP;DEBOR, MICHAELA |
分类号 |
C07D317/12;C07F9/22 |
主分类号 |
C07D317/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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