The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
申请公布号
EP3054944(A1)
申请公布日期
2016.08.17
申请号
EP20140851664
申请日期
2014.10.06
申请人
MERCK SHARP & DOHME CORP.
发明人
SHAO, NING;EDMONDSON, SCOTT D.;NEELAMKAVIL, SANTHOSH;GUO, ZHUYAN;MERTZ, ERIC;ZANG, YI;HE, JIAFANG
