CARBOXYMETHYL-GROUP-CONTAINING MODIFIED HYALURONIC ACID AND/OR SALT THEREOF AND/OR PRODUCTION METHOD FOR CARBOXYMETHYL-GROUP-CONTAINING MODIFIED HYALURONIC ACID AND/OR SALT THEREOF

摘要

A method of producing a carboxymethyl-group-containing modified hyaluronic acid and/or a salt thereof includes a step of subjecting, in a water-containing solvent having a temperature of 30°C or less, a dissolved raw material hyaluronic acid and/or a salt thereof to a reaction with a haloacetic acid and/or a salt thereof, the water-containing solvent including water or a liquid mixture of a water-soluble organic solvent and water, a ratio of the water-soluble organic solvent in the liquid mixture being 60 v/v% or less.