Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-MCM3

摘要

The present invention relates to a method aiding in the assessment of rheumatoid arthritis ("RA"). The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and anti-MCM3 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and anti-MCM3 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and anti-MCM3 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention. Further the invention relates to the use of a marker panel comprising anti-CCP and anti-MCM3 to differentiate RA from other autoimmune diseases, preferably osteoarthritis (OA).