LOCKED NUCLEIC ACID INHIBITOR OF MIR-145 AND USES THEREOF
摘要
The present invention provides oligonucleotides with chemical motifs that are miR-145 inhibitors. The oligonucleotides can be used for the treatment and prevention of a condition by inhibiting the expression or activity of miR-145 in cells of a subject in need thereof. Methods provided include treating or preventing pulmonary arterial hypertension, neointima formation, restenosis or hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors are also disclosed.
申请公布号
EP2968396(A4)
申请公布日期
2016.08.17
申请号
EP20140768310
申请日期
2014.03.13
申请人
MIRAGEN THERAPEUTICS, INC.
发明人
SETO, ANITA G.;ROOIJ, EVA VAN;ROBINSON, KATHRYN H.;DALBY, CHRISTINA M.;HULLINGER, THOMAS G.;MONTGOMERY, RUSTY