发明名称 |
RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF |
摘要 |
Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic. |
申请公布号 |
EP2838990(A4) |
申请公布日期 |
2016.08.10 |
申请号 |
EP20120874533 |
申请日期 |
2012.04.16 |
申请人 |
AERAS GLOBAL TB VACCINE FOUNDATION;INSERM - INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE |
发明人 |
FULKERSON, JOHN;BRENNAN, MICHAEL;VELMURUGAN, KAMALAKANNAN;LOCHT, CAMILLE |
分类号 |
C12N1/21;A61K39/00;A61K39/04;A61K49/00;C07K14/35;C07K19/00;C12N15/62;C12P21/00 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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