| 发明名称 |
Amiloride-like Pyrazine-carboxamides as ENaC blockers |
| 摘要 |
A compound of Formula I
in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. |
| 申请公布号 |
EP2231280(B1) |
申请公布日期 |
2016.08.10 |
| 申请号 |
EP20080860731 |
申请日期 |
2008.12.09 |
| 申请人 |
NOVARTIS AG |
发明人 |
BHALAY, GURDIP;BUDD, EMMA;BLOOMFIELD, GRAHAM CHARLES;COLLINGWOOD, STEPHEN PAUL;DUNSTAN, ANDREW;EDWARDS, LEE;GEDECK, PETER;HOWSHAM, CATHERINE;HUNT, PETER;HUNT, THOMAS ANTHONY;OAKLEY, PAUL;SMITH, NICHOLA |
| 分类号 |
C07D471/10;A61K31/497;C07D403/12;C07D471/04;C07D471/20;C07D473/34;C07D487/04;C07D487/10;C07D519/00 |
主分类号 |
C07D471/10 |
| 代理机构 |
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