发明名称 |
COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF |
摘要 |
HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency. |
申请公布号 |
EP3052662(A1) |
申请公布日期 |
2016.08.10 |
申请号 |
EP20140851396 |
申请日期 |
2014.10.01 |
申请人 |
THE J. DAVID GLADSTONE INSTITUTES |
发明人 |
WEINBERGER, LEOR;DAR, ROY |
分类号 |
C12Q1/70 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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地址 |
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