| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula or its pharmaceutically acceptable salts thereof:wherein: -Jand -J, taken together, form -CHCH-; -Q independently represents pyrid-2-yl and has n substitutes -R; or -Q independently represents pyrimidin-2-yl and has n substitutes -R; -n independently equal to 0, 1, 2 or 3; each -Rindependently represents -R, -F, -Cl, -CF, -OH, -OR, -OCF, -NH, -NHRor -NR ; each -R, if present, independently represents an unsubstituted aliphatic saturated Calkyl; -Y independently represents -OH, -OR, -F, -Cl or -CN; -Rindependently represents saturated aliphatic Calkyl; -Rindependently represents -H or -R; -Rindependently represents H or -R; each -Rindependently represents -R, -F, -Cl or -CN; each -Rrepresents saturated aliphatic Calkyl and possibly substituted with one or more groups -F; -Rindependently represents -H or -R; -Rindependently represents H or -R; each -Rindependently represents -R, -F, -Cl or -CN; each -Rrepresents saturated aliphatic Calkyl and possibly substituted with one or more groups -F; -Rindependently represents -H or -R; and -Ris a saturated aliphatic Calkyl, which are inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).EFFECT: novel compounds.63 cl, 4 tbl, 47 ex |
