发明名称 |
CRYSTALLINE PI3 KINASE INHIBITORS |
摘要 |
There is provided inter alia a dry powder pharmaceutical formulation for inhalation comprising: (i) 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof and solvates thereof in particulate form as active ingredient; (ii) particulate lactose as carrier; and (iii) a particulate stabilizing agent selected from metal salts of stearic acid such as magnesium stearate and metal salts of stearyl fumarate. |
申请公布号 |
EP2834244(B1) |
申请公布日期 |
2016.08.10 |
申请号 |
EP20130711105 |
申请日期 |
2013.03.13 |
申请人 |
RESPIVERT LIMITED |
发明人 |
BROECKX, RUDY LAURENT MARIA;FILLIERS, WALTER FERDINAND MARIA;NIESTE, PATRICK HUBERT J;COPMANS, ALEX HERMAN;VANHOUTTE, FILIP MARCEL C;LEYS, CARINA |
分类号 |
C07D487/04;A61K9/00;A61K31/519;A61K31/52;A61K47/12;A61K47/26 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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