| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to method of producing compound of formula I or its pharmaceutically acceptable salt, where Rrepresents halogen, Calkyl or Calkoxy, and Rrepresents hydrogen, which includes step for reducing compound of formula 2A to obtain compound of formula 3A and reaction of compound of formula 3A with aqueous acid to form compound of formula I. Method further involves reaction of compound of formula 4A with HONH·HCl to obtain compound of formula 2A. Compound of formula 2A is reduced to compound of formula 3A in presence of reagent containing NaBH, LiBH, KBHor any combination thereof, and catalyst which contains CoCl. Aqueous acid contains aqueous HCl or aqueous HSO. Invention also relates to compound of formula 2A.EFFECT: technical result is thiazolidinediones synthesis method, not affecting PPARγ, which are suitable for preventing and/or treating metabolic disorders, such as diabetes, obesity, hypertension and inflammatory diseases.13 cl, 1 tbl, 5 ex |
