摘要 |
PROBLEM TO BE SOLVED: To provide an improved method for coupling a carboxylic acid and an amine.SOLUTION: A solid phase peptide synthesis method comprises: combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base; and carrying out activation and coupling at a temperature greater than 30°C.SELECTED DRAWING: None |