| 摘要 |
PROBLEM TO BE SOLVED: To provide novel 6-substituted 13-demethyl-estradiol derivatives as selective ER-β agonists and analgesic agents comprising the same.SOLUTION: There is provided a 6-substituted 13-demethyl-estradiol compound represented by the following formula, where X is methoxymethyl group, 6-methoxyhexyl group, hydroxymethyl group, (aminooxy)methyl group, (methoxymethyl)amino group, methoxy group, 2-methoxyethyl group, 4-methoxybutyl group etc.; R-Rare independently H, alkyl, halogen, a sulfate, hydroxyl, aryl, cycloalkyl, heteroaryl, a phosphate group etc.; Ris H, alkyl, a glucuronide, COOH, CN, CHO etc.SELECTED DRAWING: None |
