发明名称 |
GLYCOPROTEINS HAVING LIPID MOBILIZING PROPERTIES AND THERAPEUTIC USES THEREOF |
摘要 |
The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a Zn-α2-glycoprotein or a functional fragment thereof, methods of decreasing plasma insulin levels, methods of increasing skeletal muscle mass, and methods of bringing about a weight reduction or reduction in obesity. Also provided are pharmaceutical compositions for use thereof. |
申请公布号 |
US2016220635(A1) |
申请公布日期 |
2016.08.04 |
申请号 |
US201615134097 |
申请日期 |
2016.04.20 |
申请人 |
ASTON UNIVERSITY |
发明人 |
Tisdale Michael J.;Russell Steven |
分类号 |
A61K38/17;A61K31/195;A61K31/138;A61K45/06 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
|
主权项 |
1. A method of ameliorating symptoms of hyperglycemia in a subject comprising administering to the subject in need of such treatment a therapeutically effective dosage of a polypeptide having the sequence as shown in SEQ ID NO: 1 or a fragment thereof, for a period of about 10 days or longer, wherein there is amelioration of symptoms associated with hyperglycemia following treatment. |
地址 |
Birmingham GB |