| 摘要 |
A time and cost effective production method for medical devices with a hydrophilic coating is provided, which ensures adequate adhesion to the substrate, as well as good water retention and low friction properties. Specifically, the method comprises the steps of: providing a substrate; applying, in one or more steps, a coating solution comprising a hydrophilic polymer to a surface of said substrate to form a non-cross-linked hydrophilic coating on said substrate; and irradiating the coated substrate, wherein said irradiation is adapted both to cross-link said hydrophilic coating and to simultaneously sterilize the medical device. Hereby, a non-cross linked hydrophilic coating is first obtained on the substrate, which coating is loosely connected to the substrate, and which is not fit for use as a catheter coating. However, after the step of irradiating the coated substrate, the hydrophilic coating becomes cross-linked, and fit for use e.g. on a urinary catheter. Further, since one and the same irradiation step is used to effect both crosslinking and sterilization, the production can be made more efficient, using fewer production steps and with a shortened production time. |
