发明名称 |
ENGINEERED ENZYME HAVING ACETOACETYL-COA HYDROLASE ACTIVITY, MICROORGANISMS COMPRISING SAME, AND METHODS OF USING SAME |
摘要 |
The disclosure provides engineered enzymes that are capable of mediating the conversion of acetoacetyl-CoA to acetoacetate that do not react with the same order of magnitude with acetyl-CoA as they do with acetoacetyl-CoA (e.g., the engineered enzymes have a specific acetoacetyl-CoA hydrolase activity at least 10x higher than its acetyl-CoA hydrolase activity). Additionally, the disclosure provides modified microorganisms that comprise the engineered enzymes disclosed herein and methods of using same. |
申请公布号 |
EP3049529(A1) |
申请公布日期 |
2016.08.03 |
申请号 |
EP20140845077 |
申请日期 |
2014.09.23 |
申请人 |
BRASKEM S.A. |
发明人 |
SLOVIC, AVRAM MICHAEL;GOUVEA, IURI ESTRADA;KOCH, DANIEL JOHANNES;GALZERANI, FELIPE |
分类号 |
C12P7/28 |
主分类号 |
C12P7/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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