发明名称 |
A CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR USE IN CELL THERAPY AGAINST CANCER AND INFECTIOUS DISEASE |
摘要 |
The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompasses methods for the use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases. |
申请公布号 |
EP2948544(A4) |
申请公布日期 |
2016.08.03 |
申请号 |
EP20140743792 |
申请日期 |
2014.01.28 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;NATIONAL UNIVERSITY OF SINGAPORE |
发明人 |
CAMPANA, DARIO;CHANG, YU-HSIANG |
分类号 |
C12N5/10 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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